Vanderbilt University School of Medicine

Ray Blind is always looking for postdocs!

Departments of Medicine, Biochemistry and Pharmacology

The well funded Blind lab at Vanderbilt University has several open postdoc positions to study how 2nd messenger signaling molecules alter the structure of transcription factors, and how those same signaling molecules regulate chromatin biology using functional genomics.

If you're interested in structural biology:

We recently used integrated biophysical techniques to determine the unliganded, ground-state structure of a full-length nuclear receptor bound to DNA. We now want to add regulatory ligands to this ground state to determine how activating or repressing small molecules (drugs and physiological ligands) alter the structure of this protein. The ideal candidate will need to have an interest in helping others in the lab and have skills in structural biology, protein expression/purification, NMR, X-ray crystallography and/or small angle X-ray scattering.

If you're interested in functional genomics:

We recently discovered a new gene regulatory mechanism in our lab. We have shown this enzyme generates inositide 2nd messenger signaling molecules at transcriptional start sites in chromatin, and that diffusion of these signaling molecules is somehow limited, resulting in local regulation of chromatin structure and transcription at these loci. The ideal candidate will have an interest in helping others in the lab and have skills in functional genomics. Experience with or eagerness to learn ATAC-seq, chromatin immunoprecipitation (ChIP), RNA-seq, RT-qPCR, qPCR and other gene expression analyses is ideal.

If you're interested in both:

Please apply! A structural biologist that wants to learn functional genomics, or vice versa, would be so much fun to work with!

Mentorship:

Mentorship in my lab is tailored for each person's fit with me, but the most important thing for everyone is communication. It's my goal that each trainee feels supported and listened, if that happens everything else works out. Sometimes more structure helps, sometimes less structure helps. If a trainee's confidence is low they might need me to be more hands on, but sometimes what they need is to be left alone to struggle to show themselves they can do it. Whatever the solutions are, they will come from communication. This is good for me to, if I clearly communicate why I need x,y,z for a grant or a paper, you can begin to see why that's so important to me. So if we communicate early, often and honestly, everything will be OK. I also encourage you to read about my expectations (for both you and me) here: www.blindlab.org/expectations.

If you're doubting your fit, I encourage you to take a chance and apply! I have many projects in drug design/screening, mass spectrometry, metabolomics, cell biology, nuclear biology, confocal microscopy, etc, you might be a great fit for... If you don't ask, you don't get! To apply send your CV to ray.blind@vanderbilt.edu, no need for a cover letter, just your CV.

Vanderbilt University is an equal opportunity, affirmative action employer. Women, minorities, people with disabilities, and protected veterans are encouraged to apply.

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Last updated: 2022-05-25