Florida International University

Postdoctoral Associate, Environmental Health Sciences

Brain, Behavior and the Environment Program

Neuroinflammation and Alzheimer’s disease: A postdoctoral position is available for a highly motivated candidates with background in cellular and molecular biology, neuroscience, microglia biology, or Alzheimer’s disease animal models to investigate the role of Translocator Protein 18kDA (TSPO) in the neuroinflammation associated with Alzheimer’s disease.

TSPO, previously named peripheral benzodiazepine receptor, is a glial stress response protein that has been validated as a biomarker of neuroinflammation and is widely used in preclinical and clinical studies. The Tomas Guilarte laboratory has a long history of studying TSPO as a biomarker of neuroinflammation and we have recently discovered that TSPO interacts with NADPH Oxidase-2 in microglia. We are examining the molecular, cellular, and functional aspects of this interaction in Alzheimer’s disease animal models.

This position is funded by an on-going NIH grant (ES007062-23) and the position will be for 2-3 years. See selected publications from our lab on this topic below:

Loth MK et al.: A Novel interaction of Translocator protein 18 kDa (TSPO) with NADPH Oxidase in Microglia. Molecular Neurobiology 57: 4467-4487, 2020.

Guilarte TR: TSPO in diverse CNS pathologies and psychiatric disease: a critical review and a way forward. Pharmacology & Therapeutics 194: 44-58, 2019.

Coughlin JM et al: Imaging glial cell activation and white matter integrity in brains from active and recently retired National Football League players. JAMA Neurology 74: 67-74, 2017.

Guilarte TR et al: TSPO finds NOX2 in microglia for redox homeostasis. Trends Pharmacological Sciences 37: 334-343, 2016.

Requirements: PhD in Biological sciences or neuroscience. Strong background in cellular and molecular biology, microglia biology, or in Alzheimer’ disease animal models is highly desirable..

The start date of this position is expected immediately.

Qualified candidates are encouraged to apply to Job Opening ID 523366 at facultycareers.fiu.edu and attach a cover letter and curriculum vitae in individual attachments. Candidates will be requested to provide names and contact information for at least three professional references. Review of applicants will continue until position is filled.

Florida International University (FIU) is Miami’s public research university, focused on student success. According to U.S. News and World Report, FIU has 42 top-50 rankings in the nation among public universities. FIU is a top U.S. research university (R1), with more than $200 million in annual expenditures. FIU ranks 15th in the nation among public universities for patent production, which drives innovation, and is one of the institutions that helps make Florida the top state for higher education. The Next Horizon fundraising campaign is furthering FIU’s commitment to providing students Worlds Ahead opportunities. Today, FIU has two campuses and multiple centers, and supports artistic and cultural engagement through its three museums: Patricia & Phillip Frost Art Museum, the Wolfsonian-FIU, and the Jewish Museum of Florida-FIU. FIU is a member of Conference USA, with more than 400 student-athletes participating in 18 sports. The university has awarded more than 330,000 degrees to many leaders in South Florida and beyond. For more information about FIU, visit www.fiu.edu.

FIU is a member of the State University System of Florida and an Equal Opportunity, Equal Access Affirmative Action Employer all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

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Last updated: 2022-01-16